
- exposure pathway: 口服(L1903);吸入(L1903);皮肤接触(L1903)
- Toxicity summary: 邻苯二甲酸酯是内分泌干扰物。它们减少胎儿睾丸睾酮的产生,并通过降低mRNA表达减少类固醇生成基因的表达。一些邻苯二甲酸酯也被证明可以降低胰岛素样肽3(insl3)的表达,这是一种由莱迪希细胞分泌的重要激素,对 gubernacular 韧带的发育是必需的。动物研究表明,这些效应会干扰生殖发育,并可能导致受影响幼体出现多种畸形。(A2883)
- Health Effects: 邻苯二甲酸酯是内分泌干扰物。动物研究表明它们会干扰生殖发育,并可能导致受影响幼体出现多种畸形,如肛门生殖器距离(AGD)缩短、隐睾、尿道下裂和生育能力降低。与邻苯二甲酸酯相关的效应组合被称为"邻苯二甲酸酯综合征"。(A2883)
- Symptoms and Signs: 邻苯二甲酸酯是内分泌干扰物,可引起多种发育畸形,称为"邻苯二甲酸酯综合征"。(A2883)
- Carcinogen Classification: 对人类无致癌性迹象(未被IARC列出)。
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Research chemical 1. 2mL
Research chemical 1. 2mL; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1. 2mL.




