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Product introduction

3-AP-Me is a dimethyl derivative of the nucleotide reductase inhibitor 3-AP (SML0568). 3-AP-Me can activate the endoplasmic reticulum (ER) stress pathway by promoting the phosphorylation of eIF2α and increasing the gene expression of transcription factors ATF4 and ATF6 , leading to cell apoptosis. Additionally, 3-AP-Me can activate the stress kinases c-Jun N-terminal kinase ( JNK ) and p38 mitogen-activated protein kinases. 3-AP-Me also leads to the upregulation of the spliced mRNA variant XBP1, can be used in cancer research.

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Chinese name

3-AP-Me

English name

3-AP-Me

Chinese alias

English alias

CAS number

1184391-57-8

molecular formula

C9H13N5S

molecular weight

223.3 g/mol

Exact mass

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