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Product details

名称

AP 811,NPR3拮抗剂, 钠尿肽受体 3 拮抗剂

货号

A288690-1mg

包装规格

1mg

级别

Moligand™

浓度

≥98%

产品介绍

AP 811 是一种选择性心房钠尿肽清除受体 (ANP-CR、NPR3) 拮抗剂，Ki 为 0.48 nM。AP 811 对 NPR3 的选择性比 NPR1 高 20000 倍。AP 811 消除了 ANP 引起的泵刺激。 AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation.

生化机理

高亲和力，选择性ANP清除受体（NPR3）拮抗剂（Ki = 0.45 nM）。与NPR1相比，NPR3的选择性> 20,000倍。体外抑制兔心室心肌细胞中ANP刺激的Na + / K +泵浦活性。还可以在体外以低ANP浓度阻断啮齿动物新生心肌细胞的增殖。

作用类型

拮抗剂

作用机制

钠尿肽受体 3 拮抗剂

序列

RIDR(Modifications: Arg-1 = N2-[4-(2-Naphthoylamino)phenylacetyl], Arg-4 = C-terminal (S)-2-methylbutylamide)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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