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Product introduction

Aliskiren Hydrochloride 是一种直接的肾素抑制剂，IC | 50 | = 0.72 nM。肾素是肾素-血管紧张素-醛固酮系统（RAAS）中的第一种酶，可将一种非活性肽血管紧张素原裂解为血管紧张素I。抑制肾素可防止这种裂解和随后的血管紧张素II受体活化。 Aliskiren hydrochloride is a direct renin inhibitor with an IC|50|= 0.72 nM. Renin is the first enzyme in the renin-angiotensin-aldosterone system (RAAS) and cleaves angiotensinogen, an inactive peptide, into angiotensin I. Inhibition of renin prevents this cleavage and subsequent activiation of angiotensin II receptors.

Specs ⸢ View details ⸥

Chinese name

Aliskiren Hydrochloride

English name

Aliskiren Hydrochloride

Chinese alias

盐酸阿利吉仑

English alias

AM84607 | Tox21_113592 | Aliskiren hydrochloride | (2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide hydrochloride | BSJUIBZAXCXFMZ-NATPOTRJSA-N | J-010902 | DTXSID

CAS number

173399-03-6

molecular formula

C30H54ClN3O6

molecular weight

588.22 g/mol

Exact mass

PSA

146.000 Å²

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