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Product introduction

Information Amenamevir Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent. Targets helicase-primase In vitro ASP2151 inhibited the in vitro replication of HSV-1. The mean EC50s of ASP2151 against HSV-1 and HSV-2 were 14 (range, 7.7 to 20) and 30 ng/ml (range, 15 to 58), respectively. In vivo In the cutaneously HSV-1-infected mouse model, ASP2151 dose dependently suppressed intradermal HSV-1 growth, with the effect reaching a plateau at a dose of 30 mg/kg of body weight/day.

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Chinese name

阿莫奈韦, 螺旋酶灵长类复合体抑制剂

English name

Amenamevir

Chinese alias

阿米那韦

English alias

ASP2151 | ASP-2151 | s5552 | 2,6-Dichlorophenylboronic acid, AldrichCPR | N-(2,6-DIMETHYLPHENYL)-N-(2-((4-(1,2,4-OXADIAZOL-3-YL)PHENYL)AMINO)-2-OXOETHYL)-1,1-DIOXOTHIANE-4-CARBOXAMIDE | Amenamevir (JAN/INN) | BS-17608 | Amenamevir [INN] | SCHEMBL2238614 |

CAS number

841301-32-4

molecular formula

C24H26N4O5S

molecular weight

482.55 g/mol

Exact mass

≥98%

PSA

131.000 Å²

Logp

2.24

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