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Product introduction

Information APTO-253 APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21) , promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4) . Targets c-Myc ; KLF4

Specs ⸢ View details ⸥

Chinese name

APTO-253

English name

APTO-253

Chinese alias

English alias

NSC789042 | NSC-789042 | A13838 | 1H-Imidazo(4,5-F)(1,10)phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)- | SCHEMBL10067266 | IrosustatSTX64 | LT-253 | AC-36395 | Lor-253(former code) | 2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenan

CAS number

916151-99-0

molecular formula

C22H14FN5

molecular weight

367.38 g/mol

Exact mass

10mM in DMSO

PSA

70.300 Å²

Logp

4.287

Technical Documents

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