Autocamtide-2-related inhibitory peptide TFA

Autocamtide-2 相关抑制肽 TFA

[Ala9]-Autocamtide 2, AIP | Autocamtide-2-Related Inhibitory Peptide

A488861-100mg

100mg

≥98%

产品介绍 Autocamtide-2-related inhibitory peptide (TFA) 是高度特异性的、CaMKII 的有效抑制剂，其 IC50 值为 40 nM。 Application Autocamtide 2-related inhibitory peptide has been used: To inhibit calmodulin kinase II (CaMKII) action in virulent Theileria infected macrophages To study its influence on oxidative stress associated with neural cell death after hypoxia-ischemia, using neonatal hippocampal slice cultures To quench the phosphorylation of recombinant synGA (GTPase-activating protein) induced by CaMKII

Calmodulin kinase II facilitates the calcium-dependent L-type calcium channels. Autocamtide 2-related inhibitory peptide action does not influence cAMP (cyclic adenosine monophosphate)-dependent protein kinase II, calmodulin-dependent protein kinase IV and protein kinase C. Increased expression of calmodulin kinase II is observed in structural heart disease, indicated by myocardial infarction. Thus, inhibition of calmodulin kinase II activity might serve as a protective effect against structural heart disease, as it is found to prevent cardiac hypertrophy, dilation and dysfunction. Potent inhibitor of calmodulin-depentent protein kinase II.

Lys-Lys-Ala-Lru-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu TFA