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Product details

名称

Amitifadine hydrochloride

分子类型

小分子

别名

盐酸阿米替拉定

英文名称

Amitifadine hydrochloride

货号

A646841-5mg

包装规格

5mg

浓度

≥99%

储存温度

2-8°C储存,干燥

运输条件

冰袋运输

产品介绍

Amitifadine hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) , with IC 50 s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively. In Vitro Amitifadine (DOV 21,947) is an antidepressant drug. K i values for SERT, NET, and DAT are 99 nM, 262 nM, and 213 nM. The IC 50 values for serotonin, norepinephrine and dopamine uptake are 12, 23 and 96 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo The 30 mg/kg Amitifadine dose significantly reduces nicotine self-administration. The 5 and 10 mg/kg doses reduce nicotine self-administration during the first 15 min. of the session when the greatest amount of nicotine is self-administered. The 30 mg/kg Amitifadine dose, but not the lower doses cause a significant reduction in locomotor activity averaged over the 1-hour session and reduce food motivated responding. The 10 mg/kg dose causes hypoactivity at the beginning of the session, but 5 mg/kg does not cause any hypoactivity. The effect of chronic Amitifadine treatment (10 mg/kg) over the course of 15 sessions is also determined. Amitifadine causes a significant reduction in nicotine self-administration, which is not seen to diminish over two consecutive weeks of treatment and a week after enforced abstinence. Amitifadine significantly reduces nicotine self-administration. This prompts further research to determine if Amitifadine might be an effective treatment for smoking cessation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 12 nM (serotonin), 23 nM (norepinephrine), 96 nM (dopamine)

生化机理

盐酸阿米替法汀是一种血清素-去甲肾上腺素-多巴胺再摄取抑制剂（SNDRI），在 HEK 293 细胞中对血清素、去甲肾上腺素和多巴胺的 IC 50 s 分别为 12、23 和 96 nM。

CAS号

410074-74-7

分子式

C11H12Cl3N

分子量

264.58 g/mol

PubChem编号

11680542

Isomeric SMILES

C1[C@H]2[C@@]1(CNC2)C3=CC(=C(C=C3)Cl)Cl.Cl

Smiles

C1[C@H]2[C@@]1(CNC2)C3=CC(=C(C=C3)Cl)Cl.Cl

PubChem CID

11680542

溶解性

DMSO : ≥ 100 mg/mL (377.96 mM) H2O : 50 mg/mL (188.98 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

263.004 Da

单同位素质量Monoisotopic Mass

263.004 Da

拓扑极表面积Topological Polar Surface Area

12.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

245.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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