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Product introduction

AM-1638 is a potent and orally bioavailable GPR40/FFA1 full agonist with an EC 50 of 0.16 μM. In Vivo AM-1638 exhibits moderate cross-species plasma clearance and volume of distribution, resulting in plasma half-lives suitable for evaluation of its antidiabetic properties in mouse, rat, and cynomologus monkey. Moreover, oral administration of full agonist AM-1638 demonstrates excellent oral bioavailability (mouse, >100%; rat, 72%; and cyno, 71%). AM-1638\nexhibits antidiabetic activity in BDF/DIO mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.16 μM (GPR40/FFA1)

Specs ⸢ View details ⸥

Chinese name

AM-1638

English name

AM-1638

Chinese alias

English alias

(3S)-3-cyclopropyl-3-[3-[[3-(5,5-dimethylcyclopenten-1-yl)-4-(2-fluoro-5-methoxyphenyl)phenyl]methoxy]phenyl]propanoic acid | 1142214-62-7 | SCHEMBL2495289 | (betaS)-beta-Cyclopropyl-3-[[2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-methoxy[1,1'-biphen

CAS number

1142214-62-7

molecular formula

C33H35FO4

molecular weight

514.63 g/mol

Exact mass

≥99%

PSA

55.800 Å²

Logp

7.8

Technical Documents

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