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Product details

名称

Abeprazan, 钾转运 ATP 酶抑制剂

分子类型

小分子

别名

阿贝拉赞

英文别名

英文名称

Abeprazan

货号

A648041-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan inhibits H + , K + - ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases. In Vitro The mechanism of action of Abeprazan is reversibly binding to H + , K + ‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Abeprazan inhibits acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion was equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

生化机理

Abeprazan (DWP14012) 是一种钾竞争性酸阻断剂。Abeprazan 通过可逆的钾竞争性离子结合抑制 H + , K + - ATPase，无需酸激活。Abeprazan 是作为质子泵抑制剂的潜在替代药物而开发的。

CAS号

1902954-60-2

分子式

C19H17F3N2O3S

分子量

410.41 g/mol

PubChem编号

122662112

Isomeric SMILES

CNCC1=CN(C(=C1OC)C2=C(C=C(C=C2)F)F)S(=O)(=O)C3=CC=CC(=C3)F

IIUPAC Name

1-[5-(2,4-difluorophenyl)-1-(3-fluorophenyl)sulfonyl-4-methoxypyrrol-3-yl]-N-methylmethanamine

INCHI

1S/C19H17F3N2O3S/c1-23-10-12-11-24(28(25,26)15-5-3-4-13(20)8-15)18(19(12)27-2)16-7-6-14(21)9-17(16)22/h3-9,11,23H,10H2,1-2H3

InChi Key

OUNXGNDVWVPCOL-UHFFFAOYSA-N

Smiles

CNCC1=CN(C(=C1OC)C2=C(C=C(C=C2)F)F)S(=O)(=O)C3=CC=CC(=C3)F

PubChem CID

122662112

关联CAS

1902954-60-2

MeSH Entry Terms

1H-pyrrole-3-methanamine, 5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-N-methyl-;5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-N-methyl-1H-pyrrole-3-methanamine;abeprazan;DWP-14012;DWP14012;fexuprazan

溶解性

DMSO : 50 mg/mL (121.83 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

410.091 Da

单同位素质量Monoisotopic Mass

410.091 Da

拓扑极表面积Topological Polar Surface Area

68.700 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

618

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.2

ALogP

3.2

作用类型

抑制剂

作用机制

钾转运 ATP 酶抑制剂

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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