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Product details

名称

ASP2905

分子类型

小分子

英文名称

ASP2905

货号

A648825-5mg

包装规格

5mg

级别

Moligand™

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

ASP2905 is a potent and selective potassium channel Kv12.2 inhibitor encoded by the Kcnh3/BEC1 gene. ASP2905 can cross the blood-brain barrier and has antipsychotic activities. In Vivo ASP2905 treatment inhibits hyperlocomotion induced by Phencyclidine. And significantly ameliorates Phencyclidine-induced prolongation of immobility time in mice subjected to the forced swimming test. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male ddY mice (aged 4-5 weeks) injected with Phencyclidine hydrochloride (PCP)Dosage: 0.01 mg/kg, 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg Administration: Oral administration; once Result: Inhibited hyperlocomotion induced by Phencyclidine. Form:Solid

生化机理

ASP2905 是由 Kcnh3/BEC1 基因编码的有效且选择性的钾通道 Kv12.2 抑制剂。ASP2905 可以穿越血脑屏障并具有抗精神病活性。

CAS号

792184-90-8

分子式

C20H17FN8

分子量

388.40 g/mol

PubChem编号

46913817

Isomeric SMILES

C1=CC=C(C=C1)NC2=NC(=NC(=N2)NCC3=NC=CC=N3)NC4=CC=C(C=C4)F

IIUPAC Name

2-N-(4-fluorophenyl)-4-N-phenyl-6-N-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine

INCHI

1S/C20H17FN8/c21-14-7-9-16(10-8-14)26-20-28-18(24-13-17-22-11-4-12-23-17)27-19(29-20)25-15-5-2-1-3-6-15/h1-12H,13H2,(H3,24,25,26,27,28,29)

InChi Key

APYUZVKHUKMAIJ-UHFFFAOYSA-N

Smiles

C1=CC=C(C=C1)NC2=NC(=NC(=N2)NCC3=NC=CC=N3)NC4=CC=C(C=C4)F

PubChem CID

46913817

MeSH Entry Terms

ASP2905;N-(4-fluorophenyl)-N'-phenyl-N'-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine

溶解性

DMSO : 100 mg/mL (257.47 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

388.156 Da

单同位素质量Monoisotopic Mass

388.156 Da

拓扑极表面积Topological Polar Surface Area

101.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

463.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.000

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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