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名称

ALS-8112

分子类型

小分子

英文别名

英文名称

ALS-8112

货号

A648901-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

ALS-8112 is a potent and selective respiratory syncytial virus ( RSV ) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC 50 of 0.02 μM. In Vitro The 5'-triphosphate form of ALS-8112 (ALS-8112-TP) is the active form of the drug and selectively inhibits RSV polymerase through chain termination of RNA synthesis. ALS-008112 enters various types of epithelial cells in the respiratory tract and is subsequently phosphorylated to form an intracellular nucleoside triphosphate with a half-life of approximately 29 hours. The nucleoside triphosphate analogue inhibits RSV replication by means of chain termination. ALS-8112 is a pan-strain inhibitor of RSV replication in vitro . The RNA transcription activity of the RSV–RNP complex is dose-proportionally inhibited by ALS-8112-TP with an IC 50 of 0.020 ± 0.008 μM . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.02 μM ( RSV )

生化机理

ALS-8112 是一种强效的选择性呼吸道合胞病毒（RSV）聚合酶抑制剂。ALS-8112 的 5'-triphosphate 形式可抑制 RSV 聚合酶，其 IC 50 为 0.02 μM。

CAS号

1445379-92-9

分子式

C10H13ClFN3O4

分子量

293.68 g/mol

PubChem编号

71621663

Isomeric SMILES

C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@](O2)(CO)CCl)O)F

IIUPAC Name

4-amino-1-[(2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

INCHI

1S/C10H13ClFN3O4/c11-3-10(4-16)7(17)6(12)8(19-10)15-2-1-5(13)14-9(15)18/h1-2,6-8,16-17H,3-4H2,(H2,13,14,18)/t6-,7+,8-,10-/m1/s1

InChi Key

AWSRKKBIPSQHOJ-IBCQBUCCSA-N

Smiles

C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)CCl)O)F

PubChem CID

71621663

关联CAS

1445379-92-9

溶解性

DMSO : ≥ 47 mg/mL (160.04 mM)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

293.058 Da

单同位素质量Monoisotopic Mass

293.058 Da

拓扑极表面积Topological Polar Surface Area

108.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

446.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

-1.200

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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