AC-262536

小分子

AC-262536

A649239-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

AC-262536 is a selective and non-steroidal androgen receptor modulators ( SARMs ) with beneficial anabolic effects. AC-262536 exhibits potent agonist activity at the androgen receptor , with an affinity in the low nanomolar range (1-10 nM). In Vitro AC-262536 dose-dependently inhibits dihydroxytestosterone (DHT)-induced proliferation of LNCaP. The effects are significant with 100 nM AC-262536 (%inhibition 47.2±12.2), and reaches a plateau with 1 μM treatment (%inhibition 50.7±7.6). Thus, AC-262536 can act as a functional antagonist in prostate cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo AC-262536 (3, 10, 30 mg/kg) reverses the luteinizing hormone (LH) spike in castrated rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats (200-225 g) Dosage: 3, 10 and 30 mg/kg Administration: Administered subcutaneously; once daily for 14 consecutive days Result: Significantly decreased LH levels by about 40% at the 3 mg/kg dose. The ED 50 was determined to be 2.8 mg/kg. At the 10 and 30 mg/kg doses, the effects of AC-262536 were significantly stronger than Testosterone Propionate (TP) : 1.91±0.32 ng/mL and 1.53±0.34 ng/mL vs. 3.12±0.69 ng/mL, respectively. Form:Solid

AC-262536 是一种选择性非甾体雄激素受体调节剂（SARMs），具有有益的合成代谢作用。AC-262536 对雄激素受体具有强大的激动活性，亲和力在纳摩尔级（1-10 nM）。

870888-46-3

C18H18N2O

278.35 g/mol

44512434

C1C[C@H]2CC(C[C@@H]1N2C3=CC=C(C4=CC=CC=C43)C#N)O

C1C[C@H]2CC(C[C@@H]1N2C3=CC=C(C4=CC=CC=C43)C#N)O

44512434

DMSO : 50 mg/mL (179.63 mM; ultrasonic and warming and heat to 60°C)

1

3

1

278.142 Da

278.142 Da

47.300 Ų

21

0

428.000

0

1

3.500