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名称

Acivicin hydrochloride

别名

盐酸阿西维星

英文名称

Acivicin hydrochloride

货号

A649862-5mg

包装规格

5mg

浓度

≥99%

储存温度

2-8°C储存

运输条件

冰袋运输

产品介绍

Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus , is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties In Vitro Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days) has an IC 50 of 0.7 μM in human HepG2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Acivicin hydrochloride (AT-125 hydrochloride; 5 mg/kg; IP; twice weekly) reduces urinary γ-GT by 70-78%. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to TolueneDosage: 5 mg/kg Administration: IP; twice weekly (monday and wednesday) Result: Reduced urinary γ-GT by 70-78%. Form:Solid IC50& Target:γ-glutamyl transpeptidase

生化机理

盐酸阿维菌素（AT-125 hydrochloride）是一种由链霉菌（Streptomyces sviceus）产生的天然产物，是一种γ-谷氨酰转肽酶（GGT）抑制剂。盐酸阿维菌素可透过血脑屏障，具有抗癌、抗寄生虫等特性[......]。

CAS号

161922-40-3

分子式

C5H8Cl2N2O3

分子量

215.03 g/mol

PubChem编号

155905759

IIUPAC Name

(2S)-2-amino-2-[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid;hydrochloride

INCHI

1S/C5H7ClN2O3.ClH/c6-3-1-2(11-8-3)4(7)5(9)10;/h2,4H,1,7H2,(H,9,10);1H/t2-,4-;/m0./s1

InChi Key

IXBPTDHBIYEQHX-QYEIVYHBSA-N

Smiles

C1C(ON=C1Cl)C(C(=O)O)N.Cl

PubChem CID

155905759

溶解性

DMSO : 100 mg/mL (465.05 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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