ABMA

未知

ABMA

A650277-50mg

50mg

≥98%

-20°C储存

超低温冰袋运输

ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses , intracellular bacteria and parasite . ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity In Vitro ABMA protects cells against four bacterial toxins ( Corynebacterium diphtheriae (DT; EC 50 of 62.9 μM), Bacillus anthracis (LT), Clostridium difficile toxin B (TcdB; EC 50 of 73.3 µM), Clostridium sordellii lethal toxin (TcsL; EC 50 of 86.7 μM)), three viruses (Ebola (EC 50 of 3.3 µM), rabies (EC 50 of 19.4 µM), dengue-4 virus ( EC 50 of 8.2 µM)), two species of Chlamydiales intracellular bacteria ( Simkania negevensis and Chlamydia trachomatis ), and the parasite Leishmania infantum (EC 50 of 7.1 µM) at micromolar level. In A549 cells, ABMA treatment induces a decrease in ricin cytotoxicity with an EC 50 of 3.8 µM, and a protection factor (R) at 30 µM ranging from 5 to 10. ABMA retained almost 100% of its biological activity against ricin-induced cytotoxicity up to six days. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo ABMA (2-200 mg/kg; intraperitoneal injection; female BALB/c mice) treatment protects mice from nasal instillation of an LD 90 of ricin . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Pathogen-free female BALB/c mice (6 week-old) with ricin Dosage: 2 mg/kg, 20 mg/kg, 200 mg/kg Administration: Intraperitoneal injection Result: A statistically significant protection according to survival curves was observed with a single ip dose of 2 mg/kg. The 20 mg/kg dose fully protected animals through to day 21. The 200 mg/kg dose resulted in 80% of protection of mice against ricin challenge with a single animal succumbing on day 15. Form:Solid IC50& Target:Intracellular bacteria, Viruses, Parasite

ABMA 是一种广谱的细胞内毒素和病原体抑制剂。ABMA 能有效保护细胞免受各种毒素和病原体（包括病毒、细胞内细菌和寄生虫）的侵害。ABMA 可选择性地作用于宿主细胞的晚期内体，而非宿主细胞。

332108-65-3

C18H24BrNO

350.29 g/mol

2853512

COC1=C(C=C(C=C1)Br)CNC23CC4CC(C2)CC(C4)C3

N-[(5-bromo-2-methoxyphenyl)methyl]adamantan-1-amine

1S/C18H24BrNO/c1-21-17-3-2-16(19)7-15(17)11-20-18-8-12-4-13(9-18)6-14(5-12)10-18/h2-3,7,12-14,20H,4-6,8-11H2,1H3

UCAHJECAHMOSHI-UHFFFAOYSA-N

COC1=C(C=C(C=C1)Br)CNC23CC4CC(C2)CC(C4)C3

2853512

DMSO : 125 mg/mL (356.85 mM; Need ultrasonic)

1

2

4

349.104 Da

349.104 Da

21.300 Ų

21

0

344.000

0

1

4.600