Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV , HBV and HCV . Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC 50 s ranging from 0.03 to 6.92 nM) and HIV-2 (EC 50 s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains In Vitro Azvudine (RO-0622) hydrochloride displays strong inhibition on wild-type HIV-1 IIIB and HIV-1 RF with an EC 50 ranging from 30 to 110 pM. The EC 50 values of Azvudine hydrochloride against HIV-1 KM018 , HIV-1 TC-1 and HIV-1 WAN T69N are 6.92, 0.34 and 0.45 nM, respectively. Azvudine is sensitive to NRTIs-resistant strain HIV-1 74V , PIs-resistant strains HIV-1 L10R/M46I/L63P/V82T/I84V and HIV-1 RF V82F/184V , and FIs-resistant strain pNL4-3 gp41 (36G) V38A/N42T . The EC 50 values of Azvudine hydrochloride against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:HIV-1 0.03-6.92 nM (EC 50 ) HIV-2 0.018-0.02 nM (EC 50 )