ALS-8112

ALS-8112

A655621-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

ALS-8112 is a potent and selective respiratory syncytial virus ( RSV ) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC 50 of 0.02 μM. In Vitro The 5'-triphosphate form of ALS-8112 (ALS-8112-TP) is the active form of the drug and selectively inhibits RSV polymerase through chain termination of RNA synthesis. ALS-008112 enters various types of epithelial cells in the respiratory tract and is subsequently phosphorylated to form an intracellular nucleoside triphosphate with a half-life of approximately 29 hours. The nucleoside triphosphate analogue inhibits RSV replication by means of chain termination. ALS-8112 is a pan-strain inhibitor of RSV replication in vitro . The RNA transcription activity of the RSV–RNP complex is dose-proportionally inhibited by ALS-8112-TP with an IC 50 of 0.020 ± 0.008 μM . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 0.02 μM ( RSV )

ALS-8112 是一种强效的选择性呼吸道合胞病毒（RSV）聚合酶抑制剂。ALS-8112 的 5'-triphosphate 形式可抑制 RSV 聚合酶，其 IC 50 为 0.02 μM。

1445379-92-9(DMSO)

C10H13ClFN3O4

293.68 g/mol

C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)CCl)O)F