ADRA1D receptor antagonist 1

ADRA1D 受体拮抗剂 1

ADRA1D receptor antagonist 1

A655899-1ml

1ml

10mM in DMSO

避光,干燥,-80℃储存

超低温冰袋运输

ADRA1D receptor antagonist 1 is a potent, selective and orally active α 1D adrenoceptor antagonist, with a K i of 1.6 nM In Vitro ADRA1D receptor antagonist 1 shows low hERG inhibition. ADRA1D receptor antagonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo ADRA1D receptor antagonist 1 (4.4 µg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rat with bladder outlet obstruction (BOO) Dosage: 4.4 µg/kg Administration: Intravenous injection Result: Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO. IC50& Target:Ki: 1.6 nM (α 1D adrenoceptor)

ADRA1D 受体拮抗剂 1 是一种强效、具有选择性和口服活性的 α 1D 肾上腺素受体拮抗剂，其 K i 为 1.6 nM。

1191908-14-1(DMSO)

C15H14Cl2N4O

337.20 g/mol

O=C(C1=CC(Cl)=CN([C@@H](C2=CC=CC(C#N)=C2)C)C1=N)N.[H]Cl