ABT-072, 丙型肝炎病毒 NS5B RNA 依赖性 RNA 聚合酶抑制剂

ABT-072

A656133-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

ABT-072 is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC 50 =1 nM; HCV GT1b EC 50 =0.3 nM) In Vitro ABT-072 is a non-nucleoside NS5B polymerase inhibitor with nanomolar potency in vitro against genotype 1a and 1b hepatitis C virus polymerases. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo ABT-072 (5 and/or 30 mg/kg; i.v. or p.o.) shows good PK properties. ABT-072 (2.5 and/or 30 mg/kg; i.v. or p.o.) shows low plasma clearance and high oral bioavailability. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: RatsDosage: 5 and/or 30 mg/kg (Pharmacokinetic Analysis) Administration: I.v. or p.o. Result: Showed good PK properties. Animal Model: DogDosage: 2.5 or 30 mg/kg (Pharmacokinetic Analysis) Administration: I.v. or p.o. Result: Showed low plasma clearance and high oral bioavailability. IC50& Target:NS5B polymerase

ABT-072 是一种口服活性强效非核苷类 HCV NS5B 聚合酶抑制剂（HCV GT1a EC 50 =1 nM；HCV GT1b EC 50 =0.3 nM）。

1132936-00-5(DMSO)

C24H27N3O5S

469.55 g/mol

CC(C)(C)C1=CC(=CC(=C1OC)C=CC2=CC=C(C=C2)NS(=O)(=O)C)N3C=CC(=O)NC3=O

抑制剂

丙型肝炎病毒 NS5B RNA 依赖性 RNA 聚合酶抑制剂