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名称

Amelubant

别名

阿梅卢班特

英文名称

Amelubant

货号

A656235-1ml

包装规格

1ml

级别

Moligand™

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

Amelubant (BIIL 284) 是一种有效、长效的 LTB4 receptor 拮抗剂，对 LTB4 受体的结合亲和性很低，在细胞和细胞膜中，Ki 值分别为 221 nM 和 230 nM。Amelubant (BIIL 284) 是活性代谢物 BIIL 260 和 BIIL 315 的前体。具有抗炎活性。 Amelubant (BIIL 284) is a potent, oral and long acting LTB 4 receptor antagonist, negligibly binds to LTB 4 receptor, with K i s of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a proagent of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity In Vitro Amelubant is a prodrug of active metabolites BIIL 260 and BIIL 315, which are reversible and competitive LTB 4 receptor antagonists, with K i s of 1.4, 1.1 nM and 1.7, 1.9 nM in vital cells and membranes, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:LTB 4 221 nM (Ki, in vital human granulocytes) LTB 4 230 nM (Ki, in cell membranes)

生化机理

Amelubant（BIIL 284）是一种强效、口服、长效的 LTB 4 受体拮抗剂，与 LTB 4 受体的结合可忽略不计，在重要细胞和膜中的 K i s 分别为 221 nM 和 230 nM。Amelubant (BIIL 284) 是活性代谢物 BIIL 260 和 BIIL

CAS号

346735-24-8(DMSO)

分子式

C33H34N2O5

分子量

538.63 g/mol

Smiles

CC(C1=CC=C(OCC2=CC(COC3=CC=C(C(NC(OCC)=O)=N)C=C3)=CC=C2)C=C1)(C4=CC=C(O)C=C4)C

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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