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Product details

名称

AZD8329, 羟基类固醇 11-beta 脱氢酶 1 抑制剂

分子类型

小分子

英文名称

AZD8329

货号

A656275-1ml

包装规格

1ml

级别

Moligand™

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

AZD8329 是一种有效的 11β-羟甾类脱氢酶 1 型 (11β-HSD1) 抑制剂，对人11β-HSD1 的IC50 值为 9 nM，与 11β-HSD2、17β-HSD1、17β-HSD3 相比，表现出良好的选择性。 AZD8329 is a potent 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC 50 of 9 nM for human 11β-HSD1, displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3 In Vitro AZD8329 shows IC 50 s of 0.009, 0.0086, 0.008, 0.024, 0.002 and 6.1 μM for human enzyme, rat enzyme, dog enzyme, cyno enzyme, human adipocyte and mouse enzyme, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 9 nM (Human 11β-HSD1)

生化机理

AZD8329 是一种强效的 11β-Hydroxysteroid dehydrogenase type 1（11β-HSD1）抑制剂，对人类 11β-HSD1 的 IC 50 为 9 nM，对 11β-HSD2、17β-HSD1 和 17β-HSD3 具有极佳的选择性。

CAS号

1048668-70-7(DMSO)

分子式

C25H31N3O3

分子量

421.53 g/mol

Smiles

CC(C)(C)C1=C(C=NN1C2=CC=C(C=C2)C(=O)O)C(=O)NC3C4CC5CC(C4)CC3C5

作用类型

抑制剂

作用机制

羟基类固醇 11-beta 脱氢酶 1 抑制剂

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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