Abemaciclib metabolite M18 hydrochloride

Abemaciclib 代谢物 M18 盐酸盐

Abemaciclib metabolite M18 hydrochloride

A658656-5mg

5mg

≥98%

2-8°C储存,干燥

冰袋运输

Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib ( HY-16297A ), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader Appearance:Solid IC50& Target:CDK4 CDK6 In Vitro:Abemaciclib metabolite M18 hydrochloride exhibits T 1/2 of 43.1 hr in plasma in healthy subjects. CDK4/6 inhibitors’ chief mechanism of action is inhibition of retinoblastoma (RB) protein phosphorylation and thus the induction of cell cycle arrest, C In Vivo:CDK4/6 inhibitors results T-cell persistence and immunologic memory increasing in mice receiving tumor-specific CD8 + T cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib ( HY-16297A ), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader

C25H29ClF2N8O

531 g/mol

FC(C=N1)=C(C2=CC(N(C(C)C)C(CO)=N3)=C3C(F)=C2)N=C1NC4=NC=C(C=C4)CN5CCNCC5.[H]Cl

DMSO : 125 mg/mL (235.40 mM; Need ultrasonic) H2O : 100 mg/mL (188.32 mM; Need ultrasonic)

包含CDK，MAPK，GSK3，CLK家族