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名称

AFM-30a hydrochloride

别名

AFM-30a盐酸盐

英文名称

AFM-30a hydrochloride

货号

A659162-5mg

包装规格

5mg

浓度

≥99%

储存温度

2-8°C储存,避光,干燥

运输条件

冰袋运输

产品介绍

AFM-30a hydrochloride is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a hydrochloride binds to PAD2 with an EC 50 value of 9.5 μM. AFM-30a hydrochloride also inhibits H3 citrullination with an EC 50 valu Appearance:Solid IC50& Target:EC50: 9.5 μM (PAD2); 0.4 μM (H3 citrullination) In Vitro:AFM-30a hydrochloride (compound 30a; 25 μM) has good potency to enter HEK293T/PAD2 cells and covalent modify PAD2 with an EC 50 of 9.5 μM. AFM-30a hydrochloride shows good ability to inhibit H3 citrullination with an EC 50 of 0.4 μM. MCE has not In Vivo:AFM-30a hydrochloride suppresses NLRP3 signaling and decreases airway remodeling in PAD2 -/- transgenic mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:AFM-30a hydrochloride is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a hydrochloride binds to PAD2 with an EC 50 value of 9.5 μM. AFM-30a hydrochloride also inhibits H3 citrullination with an EC 50 valu

分子式

C24H28ClFN6O3

分子量

502.97 g/mol

Smiles

O=C(C1=C2C(NCC2=CC=C1)=O)N[C@H](C3=NC4=C(N3C)C=CC=C4OC)CCCNC(CF)=N.[H]Cl

溶解性

DMSO : 50 mg/mL (99.41 mM; ultrasonic and warming and heat to 60°C) H2O : 50 mg/mL (99.41 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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「No technical documents」

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「No related articles yet」

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