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名称

AZD 2066 hydrate

别名

AZD2066 水合物

英文名称

AZD 2066 hydrate

货号

A659396-5mg

包装规格

5mg

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5 . AZD 2066 hydrate has antinociception effects. Appearance:Solid IC50& Target:mGluR5 In Vitro:AZD 2066 (1-10 μM) inhibits Ca 2+ response, with IC 50 s of 27.2±9.1, 3.56±0.52, 96.2±17.8, and 380±78.0 nM in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures respectively. AZD 2066 (1-10 μM) inhibits the oscillatory Ca 2+ response w In Vivo:AZD 2066 (0.03-30mg/kg; p.o.) shows discriminative effects in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats (weighing 240-250 g)Dosage: 0.03, 0.1, 0.3, 1, 3, Biological Activity:AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5 . AZD 2066 hydrate has antinociception effects.

分子式

C19H16ClN5O2.1/4H2O

分子量

386.33 g/mol

Smiles

CN1C(C2=CC=NC=C2)=NN=C1O[C@@H](C3=NOC(C4=CC(Cl)=CC=C4)=C3)C.O.[1/4]

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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