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名称

AKR1C3-IN-9

英文名称

AKR1C3-IN-9

货号

A659403-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

AKR1C3-IN-9 is a selective inhibitor of Aldo-keto Reductase 1C3 (AKR1C3) with an IC 50 value of 8.92 nM. AKR1C3-IN-9 significantly reverses the Doxorubicin ( HY-15142A ) (DOX) resistance in a resistant breast cancer cell line. Appearance:Solid IC50& Target:IC50: 8.92 nM (AKR1C3) In Vitro:AKR1C3-IN-9 (compound 24) (10-100 μM; 72 h and 96 h) results weak antiproliferative effect up to 100 μM in all three breast cancer cell lines (MDA-MB-231, MCF-7). AKR1C3-IN-9 (10 μM, 25 μM, and 50 μM; 72 h) synergistically inhibits the proliferation Biological Activity:AKR1C3-IN-9 is a selective inhibitor of Aldo-keto Reductase 1C3 (AKR1C3) with an IC 50 value of 8.92 nM. AKR1C3-IN-9 significantly reverses the Doxorubicin ( HY-15142A ) (DOX) resistance in a resistant breast cancer cell line.

分子式

C20H20N2O4

分子量

352.38 g/mol

Smiles

COC1=CC=CC=C1NC(C2=CC=CC=C2OCC3=C(ON=C3C)C)=O

溶解性

DMSO : 83.33 mg/mL (236.48 mM; ultrasonic and warming and heat to 60°C)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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