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Product details

名称

ABD957

英文名称

ABD957

货号

A659421-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC 50 of 0.21 µM for ABHD17B . ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells. Appearance:Solid IC50& Target:IC50: 0.21 µM (ABHD17B) In Vitro:ABD957 (500 nM; pretreated for 1 h) attenuates N-Ras depalmitoylation in AML cells. ABD957 (0.11 nM-10 μM; 72 h) blocks the signaling and proliferation of NRAS-mutant leukemia cells. MCE has not independently confirmed the accuracy of these meth Biological Activity:ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC 50 of 0.21 µM for ABHD17B . ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells.

分子式

C27H36F3N7O5S

分子量

627.68 g/mol

Smiles

C[C@H]1CN(CCN1C(N2C=CC(S(=O)(N(C)C)=O)=N2)=O)CC3=C(C=C(C=C3)C(F)(F)F)N4C5CCC4CN(C5)CC(O)=O

溶解性

DMSO : 25 mg/mL (39.83 mM; ultrasonic and warming and heat to 60°C)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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