Anatabine dicitrate

柠檬酸阿那他滨

Anatabine dicitrate

A659426-5mg

5mg

≥99%

2-8°C储存,干燥

冰袋运输

Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate is a potent α4β2 nAChR agonist. Anatabine dicitrate inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid pre Appearance:Solid IC50& Target:NF-κB Amyloid-β (Aβ) α4β2 nAChR In Vitro:Anatabine (600 μg/mL; 24 hours; SHSY-5Y cells) treatment shows an inhibition of p65 NF-κB phosphorylation. Anatabine (500-1000μg/mL; 30 minutes; SHSY-5Y cells) treatment fully prevents the increase in BACE-1 mRNA levels induced by TNF-α. After 24 hou In Vivo:Anatabine (0.5-2mg/kg; intraperitoneal injection; daily; for 4 days; transgenic mouse) treatment significantly lowers brain soluble Aβ 1-40 and Aβ 1-42 levels in a transgenic mouse model of Alzheimer's disease. MCE has not independently confirmed th Biological Activity:Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate is a potent α4β2 nAChR agonist. Anatabine dicitrate inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid pre

C22H28N2O14

544.46 g/mol

O=C(CC(C(O)=O)(O)CC(O)=O)O.O=C(CC(C(O)=O)(O)CC(O)=O)O.[C@@H]1(C2=CC=CN=C2)CC=CCN1

H2O : 100 mg/mL (183.67 mM; Need ultrasonic) DMSO : 30 mg/mL (55.10 mM; Need ultrasonic)