Share to

Details

Safety

Technical Documents

Articles

reviews

Consult

returns

Product details

名称

A-317491 sodium salt hydrate

别名

A-317491 钠盐水合物

英文名称

A-317491 sodium salt hydrate

货号

A661701-1ml

包装规格

1ml

浓度

10mM in Water

储存温度

干燥,-80℃储存

运输条件

超低温冰袋运输

产品介绍

A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of P2X 3 and P2X 2/3 receptors , with K i s of 22, 22, 9, and 92 nM for hP2X 3 , rP2X 3 , hP2X 2/3 , and rP2X 2/3 , respectively. A-317491 sodium salt hydrate is highly sele IC50& Target:P2X3 Receptor In Vitro:A-317491 potently blocks recombinant human and rat P2X 3 and P2X 2/3 receptor-mediated calcium flux (K i =22-92 nM). A-317491 (1 nM-10 μM) produces a concentration-dependent block of dorsal root ganglion (DRG) currents with an IC 50 of 15 nM. MC In Vivo:A-317491 (0.1-30mg/kg; a single s.c.) dose-dependently reverses inflammatory mechanical hyperalgesia in rats. A-317491 (3-30mg/kg; a single .v.) exhibits the plasma half-life (7.38 h), clearance rate (1.83 L/h/kg), and volume of distribution (0.17 Biological Activity:A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of P2X 3 and P2X 2/3 receptors , with K i s of 22, 22, 9, and 92 nM for hP2X 3 , rP2X 3 , hP2X 2/3 , and rP2X 2/3 , respectively. A-317491 sodium salt hydrate is highly sele

分子式

C33H29NNaO9

分子量

606.57 g/mol

Smiles

O=C(C1=CC(C(N(CC2=CC=CC(OC3=CC=CC=C3)=C2)[C@H]4CCCC5=C4C=CC=C5)=O)=C(C(O)=O)C=C1C(O)=O)O.[Na].O

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！