脱铁转铁蛋白 人

A754970-100mg

100mg

BioReagent

≥98%(agarose gel electrophoresis)

脱铁转铁蛋白已用于：培养人原代胰腺内皮细胞、Het1As（非肿瘤食管细胞）和永生化人结肠上皮细胞（HCEC-1CT）培养α小鼠肝12（AML-12）（成熟肝细胞）细胞作为晶体学前纯化的人脱铁转铁蛋白的来源应用： 转铁蛋白主要在肝脏中合成，是血清中含量丰富的糖蛋白。转铁蛋白超家族成员具有相似的多肽折叠模式。转铁蛋白含有N端和C端铁结合同源结构域。这些结构域中的每一个都被分裂成两个子结构域，在子结构域间隙内具有铁和阴离子的结合位点。绑定间隙随着铁释放和铁绑定打开和关闭。脱铁转铁蛋白是一种无铁蛋白，在转铁蛋白与其受体分离后产生。此产物可以补充铁或用于结合培养基中存在的游离铁。 Transferrin, majorly synthesized in the liver, is an abundant glycoprotein in the serum. The members of the transferrin superfamily have similar polypeptide folding patterns. Transferrin contains N- and C-terminal iron-binding homologous domains. Each of these domains is split into two subdomains having binding sites for iron and anions within the inter-subdomain cleft. The binding cleft opens and closes with iron releasing and iron binding. apo-Transferrin is an iron-free protein that arises after transferrin dissociates from its receptor. This product can be supplemented with iron or used to bind free iron present in media. Application: apo-Transferrin human has been used: to culture human primary pancreatic endothelial cells, Het1As (non-tumorous esophagus cells), and immortalized human colonic epithelial cells (HCEC-1CT) to culture α mouse liver 12 (AML-12) (mature hepatocytes) cells as a source for human apo-transferrin for purification before crystallography

转铁蛋白负责将铁从吸收和储存的部位运送到组织细胞。它能维持生物体液中的铁含量。转铁蛋白的水平可以反映总铁结合能力（TIBC）。转铁蛋白为骨髓中红细胞的血红蛋白提供所需的铁元素。缺铁会导致转铁蛋白水平升高。怀孕和服用雌激素也会提高转铁蛋白的水平。慢性肝病、肾功能不全、营养不良和蛋白质丢失性肠病会减少转铁蛋白的合成。

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