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Product introduction
AZD1480是ATP竞争性JAK2抑制剂,IC50为0.26 nM,对JAK1抑制性较弱。An inhibitor of JAK2 AZD1480 has been used as an inhibitor of janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) in an in vitro cell model of upper gastrointestinal adenocarcinoma. It has also been used in combination with bortezomib to study tumor-associated macrophage-mediated survival of myeloma cells.
Chinese name
AZD1480,JAK2抑制剂, 酪氨酸蛋白激酶 JAK2 抑制剂
English name
AZD1480
Chinese alias
-
English alias
5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine | 5-Chloro-N2-[(1s)-1-(5-Fluoropyrimidin-2-Yl)ethyl]-N4-(5-Methyl-1h-Pyrazol-3-Yl)pyrimidine-2,4-Diamine | AKOS027322548 | GTPL5933 | AM85979 | BCPP0003
CAS number
935666-88-9
molecular formula
C14H14ClFN8
molecular weight
348.77 g/mol
Exact mass
-
PSA
104.000 Ų
Logp
2.4
Technical Documents
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AZD1480 10mM in DMSO 1ml

AZD1480 10mM in DMSO 1ml Macklin 935666-88-9, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.

item number:A792277-1ml
Product model:1ml
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