
- Disposal method: SRP:在审查时,土地处理或填埋(卫生填埋)处置实践的标准正在重大修订中。在实施废物残渣(包括废物污泥)的土地处置之前,咨询环境监管机构以获取可接受的处置实践指导。
- interaction: 环磷酰胺(CP)与3-氨基苯甲酰胺(3-AB)协同增强L1210淋巴瘤细胞的姐妹染色单体交换(SCE)频率。当体内暴露于无毒浓度的3-AB时,观察到这种协同效应。当用CP处理的Ehrlich腹水瘤(EAT)细胞或P388淋巴白血病细胞在体内暴露于3-AB时,观察到SCE诱导的加性效应。3-AB增强了用CP处理的L1210肿瘤BDF1小鼠的存活时间。然而,与单独使用CP相比,CP加3-AB的联合治疗并未增加EAT BALB/c-或P388 BDF1肿瘤小鼠的存活率。因此,CP与3-AB联合使用的体内差异抗肿瘤效应似乎与体内差异...
- ecotoxicity value: USDA APHIS 化学效应:collection=usda_chemeffect&query_type=synonym&query='^3544-24-9$'
- Human toxicity extract: /遗传毒性/ 研究了5-羟甲基-2'-脱氧尿苷(HmdUrd,一种胸苷类似物)和3-氨基苯甲酰胺(3AB)对培养人淋巴细胞染色体畸变的影响。结果表明,HmdUrd是人外周淋巴细胞的有效断裂剂。当细胞用HmdUrd和3AB处理时,发现对染色单体间隙、断裂和交换有协同效应。这些发现支持以下假设:DNA中的5-羟尿嘧啶(HmUra)残基形成,然后通过5-HmUra-DNA糖基酶的作用被去除...并且3AB干扰HmUra切除后DNA修复的完成。
- Hazard categories and classifications: 特定靶器官毒性-单次接触 3 (97.8%)
- Non-human toxic extract: /遗传毒性/ 在 SVM 细胞(一种 SV40 转化的印度麂成纤维细胞系)中,已知在紫外线照射或烷基化后,姐妹染色单体交换水平异常高。已知 SVM 系在 DNA 链断裂处理方面存在缺陷。已知其他细胞中的姐妹染色单体交换会被聚(ADP-核糖)转移酶抑制剂 3-氨基苯甲酰胺刺激,该抑制剂也会延迟 DNA 断裂的修复。发现 SVM 细胞中的姐妹染色单体交换对 3-氨基苯甲酰胺或烟酰胺剥夺(同样抑制聚(ADP-核糖)基化)高度敏感;3-氨基苯甲酰胺同样会诱导 DNA 链断裂。检测姐妹染色单体交换所需的溴脱氧尿苷对 SVM 细胞毒性更大,并且本身会诱导姐妹染色单体...
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Research chemical CAS 3544-24-9 10mM 1ml
Research chemical CAS 3544-24-9 10mM 1ml, complete specifications, for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.




