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Product introduction

TC11 是一种有效的肿瘤细胞增殖抑制剂，并通过激活 caspase-3、8 和 9 诱导细胞凋亡。在长时间有丝分裂阻滞期间，它诱导 MCL1降解导致凋亡。它作为苯酞酰亚胺衍生物在结构上与免疫调节药物相关。 Information TC11 (CLT-003) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9. TC11 shows in vivo activity against multiple myeloma cell line KMS34 tumor xenografts in ICR/SCID mice. TC11 induces disruption of tubulin polymerization leading to mitotic arrest and promotes degradation of anti-apoptotic protein, MCL1, by sustained CDK1 activation.

Specs ⸢ View details ⸥

Chinese name

TC11

English name

TC11

Chinese alias

English alias

TC11 | CS-0105753 | 5-amino-2-[2,6-di(propan-2-yl)phenyl]isoindole-1,3-dione | HY-129478 | SCHEMBL2818285 | 5-Amino-2-(2,6-diisopropyl-phenyl)-isoindole-1,3-dione | AKOS040759656 | BS-47334 | 2-(2,6-diisopropylphenyl)-5-amino-1h-isoindole-1,3-dione | 1H-I

CAS number

100823-03-8

molecular formula

C20H22N2O2

molecular weight

322.40 g/mol

Exact mass

≥98%

PSA

63.400 Å²

Logp

4.500

Technical Documents

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5-amino-2-(2, 6-diisopropylphenyl)chemicalindolechemical-1, 3-diketone 97% 100mg

Name: 5-amino-2-(2, 6-diisopropylphenyl)chemicalindolechemical-1, 3-diketone 97% 100mg
Brand: 麦克林
SKU: A951720-100mg

5-amino-2-(2, 6-diisopropylphenyl)chemicalindolechemical-1, 3-diketone 97% 100mg CAS 100823-03-8, complete specifications for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：A951720-100mg

Product model：100mg

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5-amino-2-(2, 6-diisopropylphenyl)chemicalindolechemical-1, 3-diketone 97% 100mg

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