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名称
Recombinant ANGPTL3 Antibody
分子类型
抗体
别名
血管生成素样蛋白3(ANGPTL3)抗体
英文别名
ANG 5 antibody | ANG-5 antibody | ANG5 antibody | Angiopoietin 5 antibody | Angiopoietin like 3 antibody | Angiopoietin related protein 3 antibody | Angiopoietin-5 antibody | Angiopoietin-like protein 3 antibody | Angiopoietin-related protein 3 antibody |
物理外观
Liquid
货号
Ab088872-10μl
包装规格
10μl
级别
重组
浓度
见COA
储存温度
-20°C储存,避免反复冻融
运输条件
超低温冰袋运输
稳定性与储存
4°C 短期储存(1-2 周)。-20°C下长期保存(24个月)。收货后建议分装。避免冷冻/解冻循环。
储存缓冲液
10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH 7.4
防腐剂
0.02% Sodium azide
生化机理
ANGPTL3 是血管生成素样蛋白家族的成员,该家族还包括参与调节脂质代谢的 ANGPTL4 和 ANGPTL8。ANGPTL3 编码一种只在肝脏中产生并分泌到血液循环中的蛋白质。在肝脏中,ANGPTL3 只由肝细胞产生,其表达受氧固醇激活的肝 X 受体(LXR)调节。研究表明,可抑制体内和/或体外 ANGPTL3 mRNA 表达的因素包括 PPARδ、他汀类药物、胰岛素、瘦素、甲状腺激素和脂多糖等。ANGPTL3 蛋白结构包含一个介导同源异构化形成的氨基端盘卷结构域(CCD)、一个介导配体活性的羧基端纤维蛋白原样结构域(FLD)以及一个介于 CCD 和 FLD 之间的连接结构域。CCD 前面还有一个高度疏水的区域,这是典型的引导蛋白质分泌的信号肽序列。以往的研究表明,ANGPTL3 的生物效应主要体现在两个方面:调节血管生成和脂质代谢。它对血管生成有微弱的诱导作用,但通过抑制脂蛋白脂肪酶(LPL)的活性,对脂质代谢有显著的调节作用。
免疫原
A synthetic peptide derived from human ANGPTL3 (AA 17-93)
宿主种属
兔(Rabbit)
种属反应性
人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)
特异性
ANGPTL3
阳性对照
WB: Hep G2, MCF7, HeLa, A431, HEK293 and A375 cell lysates.
SDS-PAGE
150 kDa
偶联
Unconjugated
亚型
Rabbit IgG
克隆类型
重组抗体
轻链亚型
kappa
纯化方法
Protein A purified
Format
Whole IgG
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
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「No technical documents」
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「No related articles yet」
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Research chemical 10μl

Research chemical 10μl; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 10μl.

item number:Ab088872-10μl
Product model:10μl
level: 10μl
Lead Time:30days
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