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Product details

名称

Recombinant Dnmt3a Antibody

分子类型

抗体

别名

DNA甲基转移酶-3α抗体

英文别名

物理外观

Liquid

货号

Ab100246-10μl

包装规格

10μl

级别

重组

浓度

见COA

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

4°C 短期储存（1-2 周）。-20°C下长期保存（24个月）。收货后建议分装。避免冷冻/解冻循环。

储存缓冲液

10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH 7.4

防腐剂

0.02% Sodium azide

生化机理

需要进行基因组范围内的从头甲基化，对发育过程中 DNA 甲基化模式的建立至关重要。DNA 甲基化与组蛋白的甲基化相互协调。它以非进程方式对 DNA 进行修饰，也对非 CpG 位点进行甲基化。可能优先甲基化两个核糖体核心之间的 DNA 连接体，并受到组蛋白 H1 的抑制。在父系和母系印记中发挥作用。生殖细胞中大多数印记基因座的甲基化都需要它。充当 ZNF238 的转录核心抑制因子。可通过招募 HDAC 活性主动抑制转录。

免疫原

A synthetic peptide derived from human DNMT3A (AA 609-624)

宿主种属

兔(Rabbit)

种属反应性

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

特异性

DNMT3A

阳性对照

WB: HeLa and HEK293 cell lysates.

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Rabbit IgG

克隆类型

重组抗体

轻链亚型

kappa

纯化方法

Protein A purified

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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