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Product details

名称

DRP1 Mouse mAb

分子类型

抗体

别名

英文别名

物理外观

Liquid

货号

Ab100522-10μl

包装规格

10μl

级别

已验证

浓度

见COA

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

短期储存2-8℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。

储存缓冲液

10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3

防腐剂

0.02% Sodium azide

生化机理

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. May be involved in vesicle transport. Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed. Post-translational: Phosphorylation/dephosphorylation events on two sites near the GED domain regulate mitochondrial fission. Phosphorylation on Ser-637 inhibits mitochondrial fissin probably through preventing intramolecular interaction. Dephosphorylated on this site by PPP3CA which promotes mitochondrial fission. Phosphorylation on Ser-616 also promotes mitochondrial fission. Sumoylated on various lysine residues within the B domain. Desumoylated by SENP5 during G2/M transition of mitosis. Appears to be linked to its catalytic activity. S-nitrosylation increases DNM1L dimerization, mitochondrial fission and causes neuronal damage. Ubiquitination by MARCH5 affects mitochondrial morphology.

免疫原

Recombinant protein of human DNM1L (AA 1-736).

宿主种属

小鼠(Mouse)

种属反应性

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

特异性

DRP1

阳性对照

WB: HepG2, HeLa, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF7 lysates. IHC: Human kidney, ovary adenocarcinoma, bladder, bladder carcinoma tissues. IF/ICC: COS7 cells.

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Mouse IgG2b | Rabbit IgG

克隆类型

单克隆抗体

纯化方法

Protein A/G purified

克隆号

OTI3E11

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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