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Product details
名称
Recombinant FGR Antibody
分子类型
抗体
别名
FGR抗体
英文别名
SRC2 | c-fgr | c-src2 | p55-Fgr | p58-Fgr | p55c-fgr | p58c-fgr | c-src-2 proto-oncogene | EC 2.7.10 | EC 2.7.10.2 | Fgr | FLJ43153 | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | MGC75096 | p55-c-fgr protein | Proto-oncogene c-Fgr | pro
物理外观
Liquid
货号
Ab103410-10μl
包装规格
10μl
级别
重组
浓度
见COA
储存温度
-20°C储存,避免反复冻融
运输条件
超低温冰袋运输
稳定性与储存
4℃ 短期储存(1-2 周)。-20℃长期保存(24 个月)。收货后建议分装。避免冷冻/解冻循环。
储存缓冲液
10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH 7.4
防腐剂
0.02% Sodium azide
生化机理
非受体酪氨酸蛋白激酶,可传递来自细胞表面无激酶活性受体的信号,有助于调节免疫反应,包括中性粒细胞、单核细胞、巨噬细胞和肥大细胞功能、细胞骨架重塑以应对细胞外刺激、吞噬、细胞粘附和迁移。促进肥大细胞脱颗粒、释放炎性细胞因子和 IgE 介导的过敏性休克。作用于结合免疫球蛋白 Fc 区域的受体(如 MS4A2/FCER1B、FCGR2A 和/或 FCGR2B)的下游。作用于 ITGB1 和 ITGB2 的下游,调节肌动蛋白细胞骨架重组、细胞扩散和粘附。根据具体情况,可激活或抑制细胞反应。是单核细胞中 ITGB2 信号传导、吞噬和 SYK 活性的负调控因子。中性粒细胞和巨噬细胞正常的 ITGB1 和 ITGB2 信号传导、正常的细胞扩散和粘附都需要它。作为细胞迁移的正向调节因子,通过 RAC1 激活调节细胞骨架重组。体外磷酸化 SYK,促进 SYK 依赖性激活 AKT1 和 MAP 激酶信号传导。在抗原刺激的肥大细胞中磷酸化 PLD2,导致 PLD2 激活并产生信号分子溶血磷脂酸和二酰基甘油。促进 PIK3R1 的活化。磷酸化 FASLG,从而调节其泛素化和随后的内化。磷酸化 ABL1。促进 CBL、CTTN、PIK3R1、PTK2/FAK1、PTK2B/PYK2 和 VAV2 的磷酸化。磷酸化已被 SYK 磷酸化的 HCLS1,但不磷酸化未磷酸化的 HCLS1。
免疫原
A synthetic peptide derived from human FGR
宿主种属
兔(Rabbit)
种属反应性
人(Human)
特异性
FGR
阳性对照
WB: Raji lysates.
SDS-PAGE
150 kDa
偶联
Unconjugated
亚型
Rabbit IgG
克隆类型
重组抗体
轻链亚型
kappa
纯化方法
Protein A purified
Format
Whole IgG
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
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「No technical documents」
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「No related articles yet」
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Research chemical GR; 10μl

Research chemical GR; 10μl; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: GR; 10μl.

item number:Ab103410-10μl
Product model:10μl
level: GR; 10μl
Lead Time:30days
sold 559 Items
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Specifications:

10μl

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