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Product details

名称

Recombinant HIF-1 alpha Antibody

分子类型

抗体

别名

英文别名

物理外观

Liquid

货号

Ab107478-10μl

包装规格

10μl

级别

重组

浓度

见COA

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融。

储存缓冲液

10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH 7.4

防腐剂

0.02% Sodium azide

生化机理

是低氧适应性反应的主转录调节因子。在缺氧条件下，它能激活 40 多个基因的转录，包括促红细胞生成素、葡萄糖转运体、糖酵解酶、血管内皮生长因子和其他基因，这些基因的蛋白质产物能增加氧气的输送或促进新陈代谢对缺氧的适应。在胚胎血管形成、肿瘤血管生成和缺血性疾病的病理生理学中发挥重要作用。与目标基因启动子缺氧反应元件（HRE）中的核心 DNA 序列 5'-[AG]CGTG-3' 结合。激活需要招募转录辅激活子，如 CREBPB 和 EP300。与 NCOA1 或 NCOA2 相互作用可增强其活性。与氧化还原调节蛋白 APEX 的相互作用似乎能激活 CTAD，并增强 NCOA1 和 CREBBP 的激活作用。

免疫原

A synthetic peptide derived from human HIF-1 alpha (AA 616-674)

宿主种属

兔(Rabbit)

种属反应性

人(Human), 大鼠(Rat) | 人(Human),大鼠(Rat)

特异性

HIF1A

阳性对照

WB: Rat brain, MCF-7, C6, Ramos lysates. IHC: Human kindey tissue. IF/ICC: HeLa cells.

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Rabbit IgG | Mouse IgG2b

克隆类型

重组抗体

轻链亚型

kappa

纯化方法

Protein A purified

克隆号

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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