HIP2/LIG Antibody

抗体

泛素蛋白连接酶E2抗体 | 泛素蛋白连接酶E2多克隆抗体 | HIP2抗体 | HIP2多克隆抗体 | LIG抗体 | LIG多克隆抗体 | UBE2K抗体 | UBE2K多克隆抗体

E2 ubiquitin-conjugating enzyme K | EC 2.3.2.23 | HIP-2 | Huntingtin-interacting protein 2 | Ubiquitin carrier protein | Ubiquitin-conjugating enzyme E2(25K) | Ubiquitin-conjugating enzyme E2-25 kDa | Ubiquitin-conjugating enzyme E2-25K | Ubiquitin-protei

Liquid

Ab107542-100μl

100μL

无载体

0.5 mg/mL

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融。

10mM PBS, 0.09% Sodium azide, pH7.4

0.09% Sodium azide

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.

A KLH conjugated synthetic peptide from the N-terminal region of human UBE2K (AA 2-30).

兔(Rabbit)

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

HIP2/LIG

WB: HeLa, HEK293, U2OS, Hep G2, Jurkat, NIH/3T3 and C6 cell lysates.

150 kDa

Unconjugated

Rabbit IgG

多克隆抗体

Protein A purified + Peptide affinity purified

Whole IgG