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Product details

名称

ITM2B Mouse mAb

分子类型

抗体

别名

跨膜蛋白BRI抗体 | 跨膜蛋白BRI单克隆抗体 | ITM2B抗体 | ITM2B单克隆抗体

英文别名

物理外观

Liquid

货号

Ab111398-10μl

包装规格

10μl

浓度

见COA

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

短期储存2-8℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。

储存缓冲液

10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3

防腐剂

0.02% Sodium azide

生化机理

Functions as a protease inhibitor. Plays a role in APP processing regulating the physiological production of the beta amyloid peptide. Restricts docking of gamma-secretase to APP and access of alpha- and beta-secretase to their cleavage APP sequence. Post-translational: The C-terminal part of the ectodomain is processed by furin and related proteases producing a secreted peptide of 4 to 5 kDa. For the ABRI and ADAN variants the C-terminal secreted peptide is larger and may produce amyloid fibrils responsible for neuronal dysfunction and dementia. The remaining part of the ectodomain containing the BRICHOS domain is cleaved by ADAM10 and is secreted as a peptide of 25 kDa. The membrane-bound N-terminal fragment (NTF) of 22 kDa is further proteolytically processed by SPPL2A and SPPL2B through regulated intramembrane proteolysis producing a secreted peptide (BRI2C) and an intracellular domain (ICD) released in the cytosol.

免疫原

Recombinant protein of human ITM2B (AA 1-266).

宿主种属

小鼠(Mouse)

种属反应性

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

特异性

ITM2B

阳性对照

WB: A549, MCF7 lysates. IHC: Human Kidney tissue. Flow Cytometry: HeLa cells.

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Mouse IgG2a

克隆类型

单克隆抗体

纯化方法

Protein A/G purified

克隆号

OTI1C11

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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