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名称
Recombinant JAB1 Antibody
分子类型
抗体
别名
Jun激活区域-连接蛋白1重组兔单克隆抗体 | Jun激活区域-连接蛋白1重组兔单克隆抗体 | Jun激活区域-连接蛋白1重组兔单克隆抗体 | JAB1抗体 | JAB1重组抗体
英文别名
38 kDa Mov34 homolog antibody | COP9 (constitutive photomorphogenic) homolog subunit 5 antibody | COP9 constitutive photomorphogenic homolog subunit 5 antibody | COP9 signalosome complex subunit 5 antibody | COP9 signalosome subunit 5 antibody | Cop9 subu
物理外观
Liquid
货号
Ab111428-10μl
包装规格
10μl
级别
重组
浓度
0.7 mg/mL
储存温度
-20°C储存,避免反复冻融
运输条件
超低温冰袋运输
稳定性与储存
4℃ 短期储存(1-2 周)。-20℃长期保存(24 个月)。收货后建议分装。避免冷冻/解冻循环。
储存缓冲液
50mM Tris-Glycine, 150mM NaCl, 40% Glycerol, 0.05% BSA, 0.01% Sodium azide, pH 7.4
防腐剂
0.01% Sodium azide
生化机理
COP9 信号体复合体(CSN)的可能蛋白酶亚基,CSN 是一种参与各种细胞和发育过程的复合体。CSN 复合物是泛素(Ubl)连接途径的重要调节器,它介导 SCF 型 E3 连接酶复合物的 cullin 亚基的去二甲基化,从而降低 SCF、CSA 或 DDB2 等 SCF 型复合物的 Ubl 连接酶活性。该复合体还参与了 p53/TP53、c-jun/JUN、IkappaBalpha/NFKBIA、ITPK1 和 IRF8 的磷酸化,这可能是通过它与 CK2 和 PKD 激酶的结合实现的。CSN 依赖于 TP53 和 JUN 的磷酸化,分别促进和保护 Ubl 系统的降解。在复合物中,它可能充当催化中心,介导 Nedd8 与瓜蛋白的裂解。但它本身没有金属蛋白酶活性,需要 CSN 复合物的其他亚基。与大量受 CSN 复合物调控的蛋白质直接相互作用,证实了它在该复合物中的关键作用。
免疫原
A synthetic peptide derived from human JAB1
宿主种属
兔(Rabbit)
种属反应性
人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)
特异性
JAB1
阳性对照
WB: U-2 OS, MCF7, HeLa and C6 cell lysates.
SDS-PAGE
150 kDa
偶联
Unconjugated
亚型
Rabbit IgG
克隆类型
重组抗体
轻链亚型
kappa
纯化方法
Protein A purified
Format
Whole IgG
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
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「No technical documents」
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Research chemical 10μl; 0. 7 mg

Research chemical 10μl; 0. 7 mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 10μl; 0. 7 mg.

item number:Ab111428-10μl
Product model:10μl
level: 10μl; 0. 7 mg
Lead Time:30days
sold 705 Items
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Specifications:

10μl

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