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Product details
名称
Recombinant Jarid2 Antibody
分子类型
抗体
别名
组蛋白去甲基化酶JARID2抗体 | Jarid2抗体 | Jarid2重组抗体
英文别名
JMJ | DIDDF | JARID2 | JMJjumonji-like protein | jumonji (mouse) homolog | jumonji homolog | Jumonji | jumonji, AT rich interactive domain 2 | Jumonji/ARID domain-containing protein 2 | protein Jumonji | JARD2 antibody | JARD2_HUMAN antibody | JARID2 anti
物理外观
Liquid
货号
Ab111480-10μl
包装规格
10μl
级别
重组
浓度
1.0 mg/mL
储存温度
-20°C储存,避免反复冻融
运输条件
超低温冰袋运输
稳定性与储存
4℃ 短期储存(1-2 周)。-20℃长期保存(24 个月)。收货后建议分装。避免冷冻/解冻循环。
储存缓冲液
50mM Tris-Glycine, 150mM NaCl, 40% Glycerol, 0.05% BSA, 0.01% Sodium azide, pH 7.4
防腐剂
0.01% Sodium azide
生化机理
组蛋白甲基转移酶复合物的调节器,在心脏和肝脏发育、神经管融合过程和造血等胚胎发育过程中发挥着重要作用。通过调节组蛋白甲基转移酶的活性,促进组蛋白甲基转移酶复合物招募到目标基因上。结合 DNA 并介导 PRC2 复合物招募到胚胎干细胞中的目标基因。不具有组蛋白去甲基化酶活性,但能调节各种组蛋白甲基转移酶复合物的活性。在胚胎干细胞中,它与 PRC2 复合物结合,抑制 PRC2 复合物对组蛋白 H3 的'Lys-27'进行三甲基化(H3K27me3),从而在胚胎干细胞的分化和正常发育中发挥关键作用。在心脏细胞中,它需要通过激活 GLP1/EHMT1 和 G9a/EHMT2 组蛋白甲基转移酶对组蛋白 H3'Lys-9'(H3K9me)的甲基化来抑制细胞周期蛋白-D1(CCND1)的表达。通过与 GATA4 和 NKX2-5 相互作用,还可作为 ANF 的转录抑制因子。参与细胞增殖信号的负调控。
免疫原
A synthetic peptide derived from human Jarid2
宿主种属
兔(Rabbit)
种属反应性
人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)
特异性
Jarid2
阳性对照
WB: NIH/3T3 and C6 cell lysates.
SDS-PAGE
150 kDa
偶联
Unconjugated
亚型
Rabbit IgG
克隆类型
重组抗体
轻链亚型
kappa
纯化方法
Protein A purified
Format
Whole IgG
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
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「No technical documents」
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「No related articles yet」
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Research chemical 10μl; 1. 0 mg

Research chemical 10μl; 1. 0 mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 10μl; 1. 0 mg.

item number:Ab111480-10μl
Product model:10μl
level: 10μl; 1. 0 mg
Lead Time:30days
sold 98 Items
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10μl

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