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Product details
名称
LIN28A Antibody
分子类型
抗体
别名
LIN28A抗体 | LIN28A多抗 | LIN28A兔多抗
英文别名
CSDD1 antibody | FLJ12457 antibody | LIN 28 antibody | Lin 28 homolog A (C. elegans) antibody | Lin-28A antibody | LIN28 antibody | LIN28A antibody | LN28A_HUMAN antibody | Protein lin-28 homolog A antibody | ZCCHC1 antibody | zinc finger CCHC domain cont
物理外观
Liquid
货号
Ab113162-10μl
包装规格
10μl
级别
已验证
浓度
见COA
储存温度
-20°C储存,避免反复冻融
运输条件
超低温冰袋运输
稳定性与储存
短期储存2-8℃(1-2周);长期储存-20℃(12个月);收货后建议分装,避免反复冻融。
储存缓冲液
10mM PBS, 40% Glycerol, 0.05% Sodium azide, pH 7.4
防腐剂
0.05% Sodium azide
生化机理
作为一种 "翻译增强剂",可将特定的 mRNA 推向多聚体,从而提高蛋白质合成的效率。它与翻译机制和目标 mRNA 的结合可增加每分子 mRNA 的启动次数,并间接稳定 mRNA。与 IGF2 mRNA、MYOD1 mRNA、ARBP/36B4 核糖体蛋白 mRNA 及其自身 mRNA 结合。通过翻译上调 IGF2 的表达,对骨骼肌分化程序至关重要(相似)。通过特异性结合 miRNA 前体 let-7(pre-let-7),抑制 microRNA(miRNA)的生物生成。通过结合 pre-let-7 并招募 ZCCHC11/TUT4 尿苷酸基转移酶,导致 pre-let-7 的末端尿苷酸化。经尿苷酸化的 pre-let-7 miRNA 无法被 Dicer 处理,会发生降解。胚胎干(ES)细胞中pre-let-7的降解有助于ES细胞的维持。与此相反,miR-125 下调神经干细胞中的 LIN28A 可使 pre-let-7 得到处理。特别识别 pre-let-7 末端环路中的 5'-GGAG-3' motif。还能识别并结合末端环中含有 5'-GGAG-3' motif 的非 pre-let-7 pre-miRNA,导致其末端尿苷化并随后降解。
免疫原
A synthetic peptide derived from human LIN28A
宿主种属
兔(Rabbit)
种属反应性
人(Human), 小鼠(Mouse) | 人(Human),小鼠(Mouse)
特异性
LIN28A
阳性对照
WB: Mouse testis lysate.
SDS-PAGE
150 kDa
偶联
Unconjugated
亚型
Rabbit IgG
克隆类型
多克隆抗体
纯化方法
Antigen affinity purified
Format
Whole IgG
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
Technical Documents
「No technical documents」
Articles
「No related articles yet」
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Research chemical 10μl

Research chemical 10μl; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 10μl.

item number:Ab113162-10μl
Product model:10μl
level: 10μl
Lead Time:30days
sold 660 Items
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Specifications:

10μl

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