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Product details

名称

NGAL Mouse mAb

分子类型

抗体

别名

英文别名

物理外观

Liquid

货号

Ab113225-10μg

包装规格

10μg

浓度

≥90%(SDS-PAGE)

储存温度

2-8°C储存

运输条件

冰袋运输

稳定性与储存

长期储存2-8℃（24个月）；收货后建议分装。

储存缓冲液

20mM PBS, 0.05% ProClin 300, pH 7.2-7.4

防腐剂

0.05% ProClin 300

生化机理

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

免疫原

Recombinant NGAL protein.

宿主种属

小鼠(Mouse)

种属反应性

人(Human)

特异性

LCN2

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Mouse IgG1

克隆类型

多克隆抗体

轻链亚型

kappa

纯化方法

Antigen affinity chromatography

克隆号

1G2

配对抗体

[Ab113226] NGAL Mouse mAb as Capture antibody in LF, ELISA

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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