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Product details

名称

MDM2 Antibody

分子类型

抗体

别名

双微体2癌基因抗体 | MDM2抗体 | MDM2多抗

英文别名

物理外观

Liquid

货号

Ab114718-10μl

包装规格

10μl

级别

无载体

浓度

1.0 mg/mL

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

4°C 下运输。在 +4°C 下短期储存（1-2 周）。收货后建议分装。长期储存于 -20°C。避免冷冻/解冻循环。

储存缓冲液

0.42% Potassium phosphate, 0.87% Sodium chloride, 30% Glycerol, 0.01% Sodium azide, pH7.3

防腐剂

0.01% Sodium azide

生化机理

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.

免疫原

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human MDM2.

宿主种属

兔(Rabbit)

种属反应性

人(Human), 猴(Monkey) | 人(Human),猴(Monkey)

特异性

MDM2

阳性对照

WB: SK-OV-3 cell lysate. IHC: Human lung cancer tissue. IF/ICC: Jurkat cells.

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Rabbit IgG

克隆类型

多克隆抗体

纯化方法

Immunogen affinity purified

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

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After Sales Services

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Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！

Research chemical 10μl; 1. 0 mg

Name: Research chemical 10μl; 1. 0 mg
Brand: 阿拉丁
SKU: Ab114718-10μl

Research chemical 10μl; 1. 0 mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 10μl; 1. 0 mg.

item number：Ab114718-10μl

Product model：10μl

level： 10μl; 1. 0 mg

Lead Time：30days

sold 269 Items

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Specifications：

10μl

Qty

Research chemical 10μl; 1. 0 mg

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