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Product details

名称

MUC1/CD227 Mouse mAb

分子类型

抗体

别名

粘蛋白1(MUC1)抗体 | MUC1/CD227抗体

英文别名

MCD | PUM | MCKD | MCKD1 | ADMCKD | ADTKD2 | Ca15-3 | ADMCKD1 | CA 15-3 | MUC-1/X | MUC-1/SEC | Breast carcinoma-associated antigen DF3 | Carcinoma-associated mucin | CD227 antigen | CD227 | DF3 antigen | EMA | Episialin | H23 antigen | H23AG | KL-6 | MAM

物理外观

Liquid

货号

Ab116377-10μg

包装规格

10μg

级别

无载体

浓度

≥95%(SDS-PAGE)

储存温度

2-8°C储存,禁止冷冻

运输条件

冰袋运输

稳定性与储存

4°C 下运输。在 +4°C 下短期储存（1-2 周）。收货后建议分装。长期储存于 -20°C。避免冷冻/解冻循环。

储存缓冲液

10mM PBS, pH 7.0

生化机理

The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

免疫原

Purified human MUC1

宿主种属

小鼠(Mouse)

种属反应性

人(Human)

特异性

MUC1/CD227

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Mouse IgG3

克隆类型

单克隆抗体

轻链亚型

kappa

纯化方法

Protein A purified

克隆号

C595 (NCRC48)

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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