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Product details

名称

PSMA7/HSPC Mouse mAb

分子类型

抗体

别名

蛋白酶体PSMα7抗体 | 蛋白酶体PSMα7单克隆抗体

英文别名

物理外观

Liquid

货号

Ab123656-10μl

包装规格

10μl

浓度

见COA

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (12 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

储存缓冲液

10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3.

防腐剂

0.02% Sodium azide

生化机理

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.

免疫原

Recombinant full length protein of human PSMA7 produced in HEK293T.

宿主种属

小鼠(Mouse)

种属反应性

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

特异性

PSMA7

阳性对照

WB: HEK293T transfected with pCMV6-ENTRY PSMA7 cDNA for 48 hrs, A549, MCF7, 293T, HeLa, A431, Raji, HepG2, K562, COLO205 lysates. IHC: Human breast, pancreas, thyroid tissues.

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Mouse IgG2b

克隆类型

单克隆抗体

纯化方法

Protein A purified

克隆号

OTI5F6

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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