Share to
Details
Safety
Related
Technical Documents
Articles
reviews
Consult
returns
Product details
名称
SCAP Mouse mAb
分子类型
抗体
别名
SCAP抗体 | 固醇调节元件结合蛋白裂解激活蛋白抗体 | SCAP 小鼠 mAb
英文别名
KIAA0199 antibody | SCAP antibody | SCAP_HUMAN antibody | SREBF chaperone antibody | SREBF chaperone protein antibody | SREBP cleavage activating protein antibody | SREBP cleavage-activating protein antibody | Sterol regulatory element binding protein cle
物理外观
Liquid
货号
Ab126692-10μl
包装规格
10μl
级别
无载体
浓度
0.5 mg/mL
储存温度
-20°C储存,避免反复冻融
运输条件
超低温冰袋运输
稳定性与储存
4℃ 短期储存(1-2 周)。-20℃长期保存(12 个月)。收货后建议分装。避免冷冻/解冻循环。
储存缓冲液
10mM PBS, 30% Glycerol, 0.01% Sodium azide, pH 7.3.
防腐剂
0.01% Sodium azide
生化机理
胆固醇和脂质平衡所需的护卫蛋白。低胆固醇时,它调节 SCAP/SREBF 复合物从 ER 的输出。在固醇浓度较高时,与 INSIG 形成三元复合物,导致 SCAP 中的 ER 出口信号被掩盖,复合物保留在 ER 中。低固醇浓度会引发 INSIG 的释放、SCAP 的 SSC 结构域的构象变化、ER 输出信号的解除、COPII 包裹囊泡的招募、向高尔基复合体的运输、SREBF 在高尔基体中的蛋白水解、SREBF 的转录因子片段从膜中释放、其输入细胞核以及 LDLR、INSIG1 和甲羟戊酸途径的上调。
免疫原
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human SCAP. The exact sequence is proprietary.
宿主种属
小鼠(Mouse)
种属反应性
人(Human), 大鼠(Rat) | 人(Human),大鼠(Rat)
特异性
SCAP
阳性对照
WB: Hep G2, K562 and C6 cell lysates.
SDS-PAGE
150 kDa
偶联
Unconjugated
亚型
Mouse IgG1
克隆类型
单克隆抗体
轻链亚型
kappa
纯化方法
Protein G purified
克隆号
L92C245
Format
Whole IgG
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
Technical Documents
「No technical documents」
Articles
「No related articles yet」
user reviews
Loading...
Consultation

Warm reminder:

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.!

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ,We will handle it for you as soon as possible, thank you for your support and trust.!

Research chemical 10μl; 0. 5 mg

Research chemical 10μl; 0. 5 mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 10μl; 0. 5 mg.

item number:Ab126692-10μl
Product model:10μl
level: 10μl; 0. 5 mg
Lead Time:30days
sold 577 Items
Ask Solution engineer
Specifications:

10μl

Qty

Recommended for you