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Product details

名称

SIRT5 Mouse mAb

分子类型

抗体

别名

沉默调节蛋白5(SIRT5)单克隆抗体

英文别名

物理外观

Liquid

货号

Ab127693-10μl

包装规格

10μl

级别

已验证

浓度

见COA

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融。

储存缓冲液

10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3

防腐剂

0.02% Sodium azide

生化机理

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.

免疫原

Recombinant full length protein of human SIRT5 produced in HEK293.

宿主种属

小鼠(Mouse)

种属反应性

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

特异性

SIRT5

阳性对照

WB: HEK293T transfected with pCMV6-ENTRY SIRT5 cDNA for 48 hrs, HepG2, HeLa, A549, COS7, PC12, MCF7 lysates. IHC: Human Kidney tissue. IF/ICC: COS7 cells transiently transfected with pCMV6-ENTRY SIRT5. Flow Cytometry: HEK293T cells transfected with pCMV6-

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Mouse IgG1 | Rabbit IgG

克隆类型

单克隆抗体

轻链亚型

kappa

纯化方法

Protein G purified

克隆号

OTI2F10

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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