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Product details
名称
Recombinant SPT5 Antibody
分子类型
抗体
别名
SUPT5H抗体 | SUPT5H单抗 | SUPT5H重组兔单抗
英文别名
DRB sensitivity inducing factor large subunit | DRB sensitivity-inducing factor 160 kDa subunit | DRB sensitivity-inducing factor large subunit | DSIF large subunit | DSIF p160 | FLJ34157 | hSPT 5 | hSPT5 | SPT 5 | SPT 5H | SPT5 | SPT5H | SPT5H_HUMAN | Su
物理外观
Liquid
货号
Ab129060-10μl
包装规格
10μl
级别
重组
浓度
见COA
储存温度
-20°C储存,避免反复冻融
运输条件
超低温冰袋运输
稳定性与储存
4°C 短期储存(1-2 周)。-20°C下长期保存(24个月)。收货后建议分装。避免冷冻/解冻循环。
储存缓冲液
10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH 7.4
防腐剂
0.02% Sodium azide
生化机理
DRB 敏感性诱导因子复合物(DSIF 复合物)的组成成分,该复合物可调节 RNA 聚合酶 II 的 mRNA 处理和转录延伸。DSIF 通过刺激 RNGTT/CAP1A 的 mRNA 鸟苷酸转移酶活性来正向调节 mRNA 的封顶。DSIF 还与负伸长因子复合物(NELF 复合物)协同作用,加强启动子近端位点的转录暂停。转录暂停可促进具有延伸能力的 RNA 聚合酶 II 复合物的组装。DSIF 和 NELF 通过抑制转录延伸因子 TFIIS/S-II 来促进暂停。TFIIS/S-II 在转录暂停位点与 RNA 聚合酶 II 结合,并刺激该酶的弱内在核酸酶活性。RNA 聚合酶 II 对被阻断的转录本的切割可促进从新的 3'末端恢复转录,并可能允许通过自然暂停位点重复尝试转录。DSIF 还能正向调节转录伸长,HIV-1 核转录激活因子 Tat 有效激活转录伸长也需要 DSIF。DSIF 的作用是抑制源自 HIV-1 LTR 的转录本的转录暂停,并阻止 HIV-1 转录本在终止序列上的过早释放。
免疫原
A synthetic peptide derived from human SPT5 (AA 770-825)
宿主种属
兔(Rabbit)
种属反应性
人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)
特异性
SUPT5H
阳性对照
WB: A549, K562 and NIH/3T3 cell lysates.
SDS-PAGE
150 kDa
偶联
Unconjugated
亚型
Rabbit IgG
克隆类型
重组抗体
轻链亚型
kappa
纯化方法
Protein A purified
Format
Whole IgG
预测反应种属
苏门答腊猩猩(Sumatran orangutan)
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
Technical Documents
「No technical documents」
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「No related articles yet」
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Research chemical 10μl

Research chemical 10μl; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 10μl.

item number:Ab129060-10μl
Product model:10μl
level: 10μl
Lead Time:30days
sold 522 Items
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10μl

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