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Product details

名称

SULT1A1/STP Mouse mAb

分子类型

抗体

别名

SULT1A1/STP抗体 | SULT1A1/STP单克隆抗体 | 苯酚磺基转移酶抗体

英文别名

物理外观

Liquid

货号

Ab129730-10μl

包装规格

10μl

浓度

见COA

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

短期储存4℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。

储存缓冲液

10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3.

防腐剂

0.02% Sodium azide

生化机理

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin. Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil. Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis. May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.

免疫原

Recombinant full length protein of human SULT1A1/STP produced in HEK293T cell.

宿主种属

小鼠(Mouse)

种属反应性

人(Human)

特异性

SULT1A1/STP

阳性对照

WB: HEK293, THP-1 and Hep G2 cell lysates. IHC: Human liver, pancreas tissues. IF/ICC: COS7 cells transiently transfected with pCMV6-ENTRY SULT1A1. Flow Cytometry: HEK293T cells transfected with pCMV6-ENTRY SULT1A1.

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Mouse IgG1

克隆类型

单克隆抗体

纯化方法

Protein G purified

克隆号

OTI1G10

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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